Genetic architecture of open angle glaucoma and related determinants
نویسندگان
چکیده
منابع مشابه
Genetic architecture of open angle glaucoma and related determinants.
BACKGROUND Although the vertical cup-disc ratio (VCDR) and intraocular pressure (IOP) are important determinants of open angle glaucoma (OAG), it is unclear to what extent the genetic origin of these traits overlap with those of OAG. We evaluated whether the same genes that determine VCDR and IOP also predict OAG. METHODS Genetic risk scores were constructed from single nucleotide polymorphis...
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PURPOSETo create a quantitative basis for diagnostic criteria for primary open-angle glaucoma (POAG), and to propose an epidemiologic definition for POAG based on these, and to determine the prevalence of POAG in a general white population. METHODSOf the 7,983 subjects 55 years of age or older participating in the population-based Rotterdam Study, 6,756 subjects participated in the ophthalmic p...
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ژورنال
عنوان ژورنال: Journal of Medical Genetics
سال: 2010
ISSN: 0022-2593,1468-6244
DOI: 10.1136/jmg.2010.083337